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Hippocampal microstructural damage and memory impairment in clinically isolated syndrome
Author(s): ,
V. Planche
Affiliations:
University of Bordeaux; Inserm U862 - Neurocentre Magendie, Bordeaux; Clermont-Ferrand University Hospital, Clermont-Ferrand
,
A. Ruet
Affiliations:
University of Bordeaux; Inserm U862 - Neurocentre Magendie, Bordeaux; Bordeaux University Hospital
,
P. Coupé
Affiliations:
Laboratoire Bordelais de Recherche en Informatique, UMR CNRS 5800, Bordeaux, France
,
D. Hamel
Affiliations:
University of Bordeaux; Inserm U862 - Neurocentre Magendie, Bordeaux
,
M. Deloire
Affiliations:
Bordeaux University Hospital
,
F. Munsch
Affiliations:
University of Bordeaux; Inserm U862 - Neurocentre Magendie, Bordeaux
,
A. Saubusse
Affiliations:
Bordeaux University Hospital
,
J. Charré-Morin
Affiliations:
Bordeaux University Hospital
,
N. Moscufo
Affiliations:
Brigham and Women's Hospital, Harvard Medical School, Boston, MA, United States
,
D. Meier
Affiliations:
Brigham and Women's Hospital, Harvard Medical School, Boston, MA, United States
,
C.R. Guttmann
Affiliations:
Brigham and Women's Hospital, Harvard Medical School, Boston, MA, United States
,
V. Dousset
Affiliations:
University of Bordeaux; Inserm U862 - Neurocentre Magendie, Bordeaux; Bordeaux University Hospital
,
B. Brochet
Affiliations:
University of Bordeaux; Inserm U862 - Neurocentre Magendie, Bordeaux; Bordeaux University Hospital
T. Tourdias
Affiliations:
University of Bordeaux; Inserm U862 - Neurocentre Magendie, Bordeaux; Bordeaux University Hospital
ECTRIMS Online Library. Planche V. Oct 8, 2015; 115657
Vincent Planche
Vincent Planche
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Abstract: P732

Type: Poster

Abstract Category: MRI and cognition

Objective: Memory impairment is correlated to hippocampal atrophy in multiple sclerosis (MS) but the substrate of early memory deficit, prior to atrophy, is unknown. We investigated whether early hippocampal alterations are already present at the stage of clinically isolated syndrome suggestive of MS (CIS) and whether they are related to memory performance.

Methods: 37 CIS patients were prospectively included in a cross-sectional study and compared to 32 MS patients and 36 healthy controls. Information processing speed (IPS), working memory and episodic verbal memory were assessed. A 3T-MRI protocol was performed including FLAIR, T1-weighted and diffusion-tensor imaging.

Results: While there was no hippocampal atrophy in the CIS group, hippocampal fractional anisotropy (FA) was already significantly decreased, independently of T2 lesions. Hippocampal FA declined further in MS patients together with increased mean diffusivity (MD). In CIS, hippocampal MD was sensitively and specifically correlated with the delayed-recall task of episodic verbal memory test (r=-0.57, p=0.0002) but not with cognitive tasks unrelated to hippocampal function. Hippocampal MD was the only variable discriminating memory-impaired from memory-preserved CIS patients (AUC=0.77; sensitivity 90.0%; specificity 70.3%). In the MS group, hippocampal volume was correlated with episodic verbal memory performances, but hippocampal FA and MD were associated with global brain damage at this stage and in turn correlated with IPS scores (r=0.36, p=0.04 and r=-0.52, p=0.002).

Conclusion: Hippocampal microstructural damage precedes atrophy in CIS patients and is strongly correlated with their long term memory impairment. It suggests that an early neuropathological process contributing to memory deficit occurs in the hippocampus during the course of MS.

Disclosure: BB or his institution received research grants and/or consulting fees from Biogen, Bayer, Novartis, Genzyme, Roche, Medday, Merck-Serono, and Teva. AR or her institution received research grants and/or consulting fees from Novartis, Biogen-Idec, Merck-Serono, Bayer Healthcare, Roche, and Teva. VP thanks Clermont-Ferrand University Hospital and the Inserm MD-PhD program (Ecole de l'Inserm - Liliane Bettencourt) for personal support awards. Other authors: nothing to disclose.
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