Multiple sclerosis & sleep disorders: sleep disordered breathing - apnea hypopnea index non-REM versus REM in a community cohort of people with multiple sclerosis who report fatigue - more than just a bad night sleep
Author(s): ,
M. Gudesblatt
Affiliations:
South Shore Neurologic Associates, Patchogue
,
S. Xian
Affiliations:
South Shore Neurologic Associates, Patchogue
,
M. Zarif
Affiliations:
South Shore Neurologic Associates, Patchogue
,
B. Bumstead
Affiliations:
South Shore Neurologic Associates, Patchogue
,
L. Fafard
Affiliations:
South Shore Neurologic Associates, Patchogue
,
K. Bardhi
Affiliations:
South Shore Neurologic Associates, Patchogue
,
K. Wissemann
Affiliations:
South Shore Neurologic Associates, Patchogue
,
S. Thotam
Affiliations:
South Shore Neurologic Associates, Patchogue
M. Buhse
Affiliations:
South Shore Neurologic Associates, Patchogue; Nursing, State University of New York at Stony Brook, Stony Brook, NY, United States
ECTRIMS Online Library. Gudesblatt M. 10/08/15; 115167; 721
Mark Gudesblatt
Mark Gudesblatt
Contributions
Abstract
Abstract: EP1270

Type: e-Poster

Abstract Category: MS symptoms

Objective: Evaluate polysomnography (PSG) documented first night sleep abnormalities related to both sleep disordered breathing (SDB) and contrast the differences of SDB in Non-REM and REM sleep in a large cohort of people with multiple sclerosis (PwMS) who report fatigue.

Background: Fatigue is common and often disabling in PwMS. Fatigue as a symptom likely reflects a complex heterogeneous problem reported as a simple complaint. Improved understanding of some pathogenic aspects contributing to fatigue might lead to improved treatment efficacy and satisfaction. SDB is a common cause of daytime fatigue and impaired quality of life. Characterization of the types and degrees of SDB in PwMS and analysis of underlying sleep architecture disturbances and SDB in Non-REM and REM sleep in PwMS is limited.

Methods: Retrospective analysis of PwMS reporting fatigue, and who underwent overnight PSG studies.

Results: 206 PwMS with fatigue underwent overnight PSG. Of these patients: 64/206 (31%) had no significant SDB (AHI< 4.9), 79/ 206 (38%) exhibited mild SDB (5< AHI< 19.9), 39/206 (19%) moderate SDB (20< AHI < 39.9), and 24/206 (12%) had severe SDB (AHI>40). PSG analysis of SDB during Non-REM sleep revealed: 81/205 (40%) no SDB (AHI< 4.9), 70/205 (34%) mild SDB (5< AHI< 19.9), 36/205 (18%) moderate SDB (20< AHI< 39.9), 18/205 (9%) severe SDB (AHI > 40). In contrast PSG analysis of SDB during REM sleep of those patients who reached REM sleep (12% did not achieve REM Sleep) demonstrated: 61/181 (34%) no SDB (AHI< 4.9), 50/181 (28%) mild SDB (5< AHI< 19.9), 38/181 (21%) moderate SDB (20< AHI< 39.9), whereas 32/181 (18%) had severe SDB (AHI>40).

Conclusion: Sleep disorders are common in PwMS who report fatigue. SDB during REM sleep may be common and more severe than Non-REM SDB in PwMS who report fatigue. These differences and degree of SDB in Non-REM and REM might impact the consequence of this problem and reinforce the need for treatment.

Disclosure:

Mark Gudesblatt - nothing to disclose

Steven Xian- nothing to disclose

Myassar Zarif - nothing to disclose

Barbara Bumstead - nothing to disclose

Lori Fafard - nothing to disclose

Konstantina Bardhi - nothing to disclose

Karl Wissemann - nothing to disclose

Smitha Thotam - nothing to disclose

Marijean Buhse - nothing to disclose

Abstract: EP1270

Type: e-Poster

Abstract Category: MS symptoms

Objective: Evaluate polysomnography (PSG) documented first night sleep abnormalities related to both sleep disordered breathing (SDB) and contrast the differences of SDB in Non-REM and REM sleep in a large cohort of people with multiple sclerosis (PwMS) who report fatigue.

Background: Fatigue is common and often disabling in PwMS. Fatigue as a symptom likely reflects a complex heterogeneous problem reported as a simple complaint. Improved understanding of some pathogenic aspects contributing to fatigue might lead to improved treatment efficacy and satisfaction. SDB is a common cause of daytime fatigue and impaired quality of life. Characterization of the types and degrees of SDB in PwMS and analysis of underlying sleep architecture disturbances and SDB in Non-REM and REM sleep in PwMS is limited.

Methods: Retrospective analysis of PwMS reporting fatigue, and who underwent overnight PSG studies.

Results: 206 PwMS with fatigue underwent overnight PSG. Of these patients: 64/206 (31%) had no significant SDB (AHI< 4.9), 79/ 206 (38%) exhibited mild SDB (5< AHI< 19.9), 39/206 (19%) moderate SDB (20< AHI < 39.9), and 24/206 (12%) had severe SDB (AHI>40). PSG analysis of SDB during Non-REM sleep revealed: 81/205 (40%) no SDB (AHI< 4.9), 70/205 (34%) mild SDB (5< AHI< 19.9), 36/205 (18%) moderate SDB (20< AHI< 39.9), 18/205 (9%) severe SDB (AHI > 40). In contrast PSG analysis of SDB during REM sleep of those patients who reached REM sleep (12% did not achieve REM Sleep) demonstrated: 61/181 (34%) no SDB (AHI< 4.9), 50/181 (28%) mild SDB (5< AHI< 19.9), 38/181 (21%) moderate SDB (20< AHI< 39.9), whereas 32/181 (18%) had severe SDB (AHI>40).

Conclusion: Sleep disorders are common in PwMS who report fatigue. SDB during REM sleep may be common and more severe than Non-REM SDB in PwMS who report fatigue. These differences and degree of SDB in Non-REM and REM might impact the consequence of this problem and reinforce the need for treatment.

Disclosure:

Mark Gudesblatt - nothing to disclose

Steven Xian- nothing to disclose

Myassar Zarif - nothing to disclose

Barbara Bumstead - nothing to disclose

Lori Fafard - nothing to disclose

Konstantina Bardhi - nothing to disclose

Karl Wissemann - nothing to disclose

Smitha Thotam - nothing to disclose

Marijean Buhse - nothing to disclose

By clicking “Accept Terms & all Cookies” or by continuing to browse, you agree to the storing of third-party cookies on your device to enhance your user experience and agree to the user terms and conditions of this learning management system (LMS).

Cookie Settings
Accept Terms & all Cookies