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Multiple sclerosis & sleep disorders: sleep disordered breathing - apnea hypopnea index non-REM versus REM in a community cohort of people with multiple sclerosis who report fatigue - more than just a bad night sleep
ECTRIMS Online Library. Gudesblatt M. Oct 8, 2015; 115167; 721
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Abstract: EP1270
Type: e-Poster
Abstract Category: MS symptoms
Objective: Evaluate polysomnography (PSG) documented first night sleep abnormalities related to both sleep disordered breathing (SDB) and contrast the differences of SDB in Non-REM and REM sleep in a large cohort of people with multiple sclerosis (PwMS) who report fatigue.
Background: Fatigue is common and often disabling in PwMS. Fatigue as a symptom likely reflects a complex heterogeneous problem reported as a simple complaint. Improved understanding of some pathogenic aspects contributing to fatigue might lead to improved treatment efficacy and satisfaction. SDB is a common cause of daytime fatigue and impaired quality of life. Characterization of the types and degrees of SDB in PwMS and analysis of underlying sleep architecture disturbances and SDB in Non-REM and REM sleep in PwMS is limited.
Methods: Retrospective analysis of PwMS reporting fatigue, and who underwent overnight PSG studies.
Results: 206 PwMS with fatigue underwent overnight PSG. Of these patients: 64/206 (31%) had no significant SDB (AHI< 4.9), 79/ 206 (38%) exhibited mild SDB (5< AHI< 19.9), 39/206 (19%) moderate SDB (20< AHI < 39.9), and 24/206 (12%) had severe SDB (AHI>40). PSG analysis of SDB during Non-REM sleep revealed: 81/205 (40%) no SDB (AHI< 4.9), 70/205 (34%) mild SDB (5< AHI< 19.9), 36/205 (18%) moderate SDB (20< AHI< 39.9), 18/205 (9%) severe SDB (AHI > 40). In contrast PSG analysis of SDB during REM sleep of those patients who reached REM sleep (12% did not achieve REM Sleep) demonstrated: 61/181 (34%) no SDB (AHI< 4.9), 50/181 (28%) mild SDB (5< AHI< 19.9), 38/181 (21%) moderate SDB (20< AHI< 39.9), whereas 32/181 (18%) had severe SDB (AHI>40).
Conclusion: Sleep disorders are common in PwMS who report fatigue. SDB during REM sleep may be common and more severe than Non-REM SDB in PwMS who report fatigue. These differences and degree of SDB in Non-REM and REM might impact the consequence of this problem and reinforce the need for treatment.
Disclosure:
Mark Gudesblatt - nothing to disclose
Steven Xian- nothing to disclose
Myassar Zarif - nothing to disclose
Barbara Bumstead - nothing to disclose
Lori Fafard - nothing to disclose
Konstantina Bardhi - nothing to disclose
Karl Wissemann - nothing to disclose
Smitha Thotam - nothing to disclose
Marijean Buhse - nothing to disclose
Type: e-Poster
Abstract Category: MS symptoms
Objective: Evaluate polysomnography (PSG) documented first night sleep abnormalities related to both sleep disordered breathing (SDB) and contrast the differences of SDB in Non-REM and REM sleep in a large cohort of people with multiple sclerosis (PwMS) who report fatigue.
Background: Fatigue is common and often disabling in PwMS. Fatigue as a symptom likely reflects a complex heterogeneous problem reported as a simple complaint. Improved understanding of some pathogenic aspects contributing to fatigue might lead to improved treatment efficacy and satisfaction. SDB is a common cause of daytime fatigue and impaired quality of life. Characterization of the types and degrees of SDB in PwMS and analysis of underlying sleep architecture disturbances and SDB in Non-REM and REM sleep in PwMS is limited.
Methods: Retrospective analysis of PwMS reporting fatigue, and who underwent overnight PSG studies.
Results: 206 PwMS with fatigue underwent overnight PSG. Of these patients: 64/206 (31%) had no significant SDB (AHI< 4.9), 79/ 206 (38%) exhibited mild SDB (5< AHI< 19.9), 39/206 (19%) moderate SDB (20< AHI < 39.9), and 24/206 (12%) had severe SDB (AHI>40). PSG analysis of SDB during Non-REM sleep revealed: 81/205 (40%) no SDB (AHI< 4.9), 70/205 (34%) mild SDB (5< AHI< 19.9), 36/205 (18%) moderate SDB (20< AHI< 39.9), 18/205 (9%) severe SDB (AHI > 40). In contrast PSG analysis of SDB during REM sleep of those patients who reached REM sleep (12% did not achieve REM Sleep) demonstrated: 61/181 (34%) no SDB (AHI< 4.9), 50/181 (28%) mild SDB (5< AHI< 19.9), 38/181 (21%) moderate SDB (20< AHI< 39.9), whereas 32/181 (18%) had severe SDB (AHI>40).
Conclusion: Sleep disorders are common in PwMS who report fatigue. SDB during REM sleep may be common and more severe than Non-REM SDB in PwMS who report fatigue. These differences and degree of SDB in Non-REM and REM might impact the consequence of this problem and reinforce the need for treatment.
Disclosure:
Mark Gudesblatt - nothing to disclose
Steven Xian- nothing to disclose
Myassar Zarif - nothing to disclose
Barbara Bumstead - nothing to disclose
Lori Fafard - nothing to disclose
Konstantina Bardhi - nothing to disclose
Karl Wissemann - nothing to disclose
Smitha Thotam - nothing to disclose
Marijean Buhse - nothing to disclose
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