Mapping focal loss of the ganglion cell–inner plexiform layer in patients multiple sclerosis
ECTRIMS Online Library. Wang J. Oct 26, 2017; 200057; P402
Jianhua Wang
Jianhua Wang

Abstract: P402

Type: Poster

Abstract Category: Clinical aspects of MS - 10 Neuro-ophthalmology

Purpose: A detailed analysis of the tomographic thickness patterns of intraretinal layers may provide more sensitive information on neurodegeneration in patients with multiple sclerosis. The goal of this study was to map the ganglion cell-inner plexiform layer (GCIPL) by ultra-high-resolution optical coherence tomography (UHR-OCT).
Forty-two eyes of 42 relapsing and remitting multiple sclerosis (RRMS) patients, and 42 eyes of 42 age- (± 5 yrs) and gender-match healthy subjects were recruited. Custom made UHR-OCT (axial resolution ~3 µm) was used to acquire three dimensional volumes of the macula. Automated segmentation software (Orion, Voxeleron LLC) was used to segment the thickness of GCIPL in a diameter of 6 mm centered on the fovea. To create the average thickness map of each group, the center of fovea was aligned and the thickness in each pixel of the 512 × 128 pixels was averaged in the group, resulting in the average thickness maps. The thickness differentiation maps were calculated by subtracting the thickness of the control group from the MS groups in each pixel and partition was done using the Early Treatment Diabetic Retinopathy Study (ETDRS).
The GCIPL thickness maps showed focal thinning located in inner annulus (3 mm in diameter) and superior and nasal sectors within the outer annulus (3-6 mm in diameter), which were significantly thinner in MS compared to controls (post hoc test, P < 0.05). The most profound thinning was located in the inner inferior with a difference of 10 µm between groups.
Conclusions: Focal thinning of the GCIPL was evident in patients with RRMS and the characteristic thinning pattern may be developed as an image biomarker of retinal neurodegeneration in MS.
Disclosure: All the authors have nothing to disclose.

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