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Peripapillary and parafoveal vascular network assessment by optical coherence tomography angiography in Aquaporin-4 antibody-positive neuromyelitis optica spectrum disorders
Author(s): ,
C. Quan
Affiliations:
Fudan University | Department of Neurology, Huashan Hospital
,
Y. Huang
Affiliations:
Fudan University | Department of Ophthalmology, Eye and ENT Hospital, Shanghai, China
,
L. Zhou
Affiliations:
Fudan University | Department of Neurology, Huashan Hospital
,
J. Zhangbao
Affiliations:
Fudan University | Department of Neurology, Huashan Hospital
,
M. Wang
Affiliations:
Fudan University | Department of Ophthalmology, Eye and ENT Hospital, Shanghai, China
,
C. Zhao
Affiliations:
Fudan University | Department of Neurology, Huashan Hospital
J. Lu
Affiliations:
Fudan University | Department of Neurology, Huashan Hospital
ECTRIMS Online Library. Quan C. Oct 12, 2018; 228130
Chao Quan
Chao Quan
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Abstract
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Abstract: P1752

Type: Poster Sessions

Abstract Category: N/A

Background and aims: Current understanding of the alterations in the retinal vascular network in neuromyelitis optica spectrum disorders (NMOSD) is limited. We aim to assess the peripapillary and parafoveal vessel density in aquaporin-4 antibody-positive NMOSD patients by optical coherence tomography (OCT) angiography.
Methods: A total of 55 aquaporin-4 antibody-positive NMOSD patients with or without a history of optic neuritis (ON) and 33 healthy controls underwent spectral domain OCT and OCT angiography. Clinical histories, Expanded Disability Status Scale (EDSS) score, visual functional system score (VFSS) and disease duration were collected.
Results: Peripapillary and parafoveal vessel density was significantly decreased in NMOSD eyes with or without a history of ON. The decrease in retinal vessel density could occur before ON and retinal nerve fiber layer (RNFL) atrophy. Peripapillary vessel density correlated well with the spectral domain OCT measurements and VFSS in NMOSD eyes with a history of ON.
Conclusion: Subclinical primary retinal vasculopathy may occur in NMOSD prior to ON and RNFL atrophy. Peripapillary vessel density might be a sensitive predictor of visual outcomes in NMOSD patients with ON.
Disclosure: Nothing to disclose

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