Save
Episode of encephalitis is important clinical component of MOG antibody associated demyelination: a single center cohort study in Shanghai, China
Author(s): ,
L. Wang
Affiliations:
Fudan University | Department of Neurology, Huashan Hospital, Shanghai, China
,
C. Quan
Affiliations:
Fudan University | Department of Neurology, Huashan Hospital, Shanghai, China
,
J. Zhangbao
Affiliations:
Fudan University | Department of Neurology, Huashan Hospital, Shanghai, China
,
L. Zhou
Affiliations:
Fudan University | Department of Neurology, Huashan Hospital, Shanghai, China
,
C. Zhao
Affiliations:
Fudan University | Department of Neurology, Huashan Hospital, Shanghai, China
J. Lu
Affiliations:
Fudan University | Department of Neurology, Huashan Hospital, Shanghai, China
ECTRIMS Online Library. Quan C. Oct 12, 2018; 228142; P1764
Chao Quan
Chao Quan
Login now to access Regular content available to all registered users.

You may also access this content "anytime, anywhere" with the Free MULTILEARNING App for iOS and Android
Abstract
Discussion Forum (0)
Rate & Comment (0)

Abstract: P1764

Type: Poster Sessions

Abstract Category: N/A

Background: Except for a distinct spectrum of demyelinating syndromes, encephalitis was observed in patients with myelin oligodendrocyte glycoprotein antibody (MOG-ab).
Methods: We retrospectively reviewed the clinical records of 690 patients with suspected idiopathic demyelinating diseases of the CNS seen in our center from 2015.6-2017.12. All underwent serum aquaporin 4 antibodies (AQP4-ab) and MOG-ab detection by cell based assays as routine diagnostic approach. Patients with MOG-ab or AQP4-ab that had ever experienced encephalitis-like illness during the course were sorted out. Whether the diagnoses of possible or definite autoimmune encephalitis (AE) could be reached with regard to these particular episodes of encephalitis were judged. The incidence and clinical features of encephalitis in anti-MOG disease were described in detail and compared with that in AQP4-ab disease.
Results: Among the 690 patients, 87 were MOG-ab-positive while 140 were AQP4-ab-positive. 20.7% (18/87) of the MOG-ab-positive patients had typical presentations of encephalitis. Unique cortical lesions (72.2%, 13/18) were observed, fever (55.6%), intracranial hypertension (41.2%) and CSF pleocytosis (64.7%) were common during MOG-ab related encephalitis. Sixteen of the 18 patients fulfilled the criteria of definite AE (specific disease with MOG-ab) during encephalitis; 5 overlapped with anti-N-methyl-D-aspartate-receptor encephalitis (NMDARE). Only 3.6% (5/140) of the AQP4-ab-positive patients had encephalitis, none overlapped with NMDARE. The Expanded Disability Status Scale scores and the Cerebral Functional System Scores at last follow-up were lower in patients with MOG-ab related encephalitis than in those with AQP4-ab related encephalitis.
Conclusions: Encephalitis is relatively common and should be recognized as important clinical component in anti-MOG disease.
Disclosure: nothing to disclose

Code of conduct/disclaimer available in General Terms & Conditions
Anonymous User Privacy Preferences

Strictly Necessary Cookies (Always Active)

MULTILEARNING platforms and tools hereinafter referred as “MLG SOFTWARE” are provided to you as pure educational platforms/services requiring cookies to operate. In the case of the MLG SOFTWARE, cookies are essential for the Platform to function properly for the provision of education. If these cookies are disabled, a large subset of the functionality provided by the Platform will either be unavailable or cease to work as expected. The MLG SOFTWARE do not capture non-essential activities such as menu items and listings you click on or pages viewed.


Performance Cookies

Performance cookies are used to analyse how visitors use a website in order to provide a better user experience.



Google Analytics is used for user behavior tracking/reporting. Google Analytics works in parallel and independently from MLG’s features. Google Analytics relies on cookies and these cookies can be used by Google to track users across different platforms/services.


Save Settings