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Reproductive history in a Danish nationwide registry-based study with a century's follow-up
Author(s): ,
J.Y. Moberg
Affiliations:
Danish Multiple Sclerosis Center, Danish Multiple Sclerosis Registry, Department of Neurology, Copenhagen University Hospital, Rigshospitalet
,
B. Laursen
Affiliations:
National Institute of Public Health, University of Southern Denmark, Copenhagen, Denmark
M. Magyari
Affiliations:
Danish Multiple Sclerosis Center, Danish Multiple Sclerosis Registry, Department of Neurology, Copenhagen University Hospital, Rigshospitalet
ECTRIMS Online Library. Moberg JY. Oct 12, 2018; 228837
Julie Yoon Moberg
Julie Yoon Moberg
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Abstract: P995

Type: Poster Sessions

Abstract Category: Clinical aspects of MS - Epidemiology

Background: A diagnosis of multiple sclerosis (MS) may impact the possibility and wish of parenthood.
Objectives: To report the number of pregnancies and live births of Danish persons with MS.
Methods: From the Danish Multiple Sclerosis Registry, we extracted a cohort of persons diagnosed with MS between 1960-1996 matched with four reference persons from the background population on year of birth, sex and vital status. We obtained information on their live born children, abortions and ectopic pregnancies from nationwide Danish registries. Poisson regression adjusted for parental educational level, parental birth year, age at diagnosis, children before diagnosis and DMT before conception was used to analyse the association between the MS cohort and outcome, relative to the reference cohort. Furthermore, we wished to investigate the annual number of childbirths in the Danish MS population the last 17 years among persons with MS and in their childbearing age between 13-49 years. The live births were calculated as a percentage of the whole MS population who were alive and of childbearing age.
Results: We included 8,089 persons with MS (4,897 women) and 37,223 reference persons (23,001 women). Both women (IRR 0.41; 95% CI 0.39-0.44; p< .0001) and men with MS ( IRR 0.49; 0.46-0.53; p< .0001) had fewer children compared with reference parents. Interestingly, women with MS had fewer elective abortions after onset than reference women ( IRR 0.80; 95% CI 0.69-0.93; p=0.0037) but experienced more often ectopic pregnancies ( IRR 1.45; 95% CI 1.06-2.00; p=0.02). Spontaneous abortions were comparable to the reference women ( IRR 1.03; 95% CI 0.73-1.45; p=0.88). In total 3,127 persons (1,958 women) with MS became parents after the diagnosis of MS. Annual mean live births of women during the period 2000-2004 was 81.4 per year (1.1%) and men 46.8 (1.3%), between 2005-2009 from women was 118.0 (1.8%) and men 56.8 (1.9%) between 2010-2016 from women was 130.0 (2.8%) and men 62.1 (3.0%).
Conclusion: Having MS seems to impact the reproductive history considerably resulting in fewer children than the background population. Family planning however should be an important topic in clinical practice.
Disclosure: JY Moberg has served on a scientific advisory board for Biogen, has received speaker honoraria from Biogen, Sanofi Genzyme and Teva and has received support for congress participation from Biogen, Merck, Roche, Sanofi Genzyme and Teva.
B Laursen has nothing to disclose.
M Magyari has served on scientific advisory boards for Biogen and Teva, has received honoraria for lecturing from Biogen, Merck, Novartis and Teva and support for congress participation from Biogen, Merck, Novartis, Roche, Teva and Sanofi Genzyme.

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