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Subclinical cochlear involvement in newly diagnosed relapsing-remitting multiple sclerosis
Author(s): ,
M. Albanese
Affiliations:
Multiple Sclerosis Clinical and Research Unit, Department of Systems Medicine
,
R. Di Mauro
Affiliations:
University of Rome Tor Vergata, Rome, Italy
,
L. Boffa
Affiliations:
University of Rome Tor Vergata, Rome, Italy
,
B. Di Gioia
Affiliations:
University of Rome Tor Vergata, Rome, Italy
,
G.A. Marfia
Affiliations:
University of Rome Tor Vergata, Rome, Italy
,
D. Landi
Affiliations:
University of Rome Tor Vergata, Rome, Italy
,
F. Monteleone
Affiliations:
University of Rome Tor Vergata, Rome, Italy
,
G. Mataluni
Affiliations:
University of Rome Tor Vergata, Rome, Italy
,
C.G. Nicoletti
Affiliations:
University of Rome Tor Vergata, Rome, Italy
,
D. Centonze
Affiliations:
University of Rome Tor Vergata, Rome, Italy
,
N.B. Mercuri
Affiliations:
University of Rome Tor Vergata, Rome, Italy
S. Di Girolamo
Affiliations:
University of Rome Tor Vergata, Rome, Italy
ECTRIMS Online Library. Albanese M. Oct 12, 2018; 228857
Maria Albanese
Maria Albanese
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Abstract: P1015

Type: Poster Sessions

Abstract Category: Clinical aspects of MS - MS symptoms

Introduction: Hearing impairment in Multiple Sclerosis (MS) has long been considered a dormant and progressive process, occurring later in the disease course and typically related to a central nervous system demyelination. Recent temporal bone studies have demonstrated the presence of microglia in the coclea, supporting the hypothesis that autoimmunity mechanisms in MS may also affect the inner ear, even at early stages of the disease.
Objectives/Aims: To investigate the peripheral auditory pathway in untreated newly diagnosed MS patients by using objective, quantitative and non-invasive methods, transient-evoked (TEOAE) and distortion-product (DPOAE) otoacoustic emissions, to detect alterations of cochlear functioning and possible relations with disease severity.
Methods: Forty-five newly diagnosed patients with relapsing-remitting multiple sclerosis (RR-MS) and with no brainstem lesions have been analysed, together with forty-eight matched controls. All subjects had a routine neuro-audiological evaluation and otoacoustic emissions recordings (OAEs), including possible associations between clinical data and hearing results.
Results: Auditory brainstem evoked potentials and pure tone audiometric thresholds resulted normal between the two groups. TEOAE and DPOAE responses were lower at the frequencies of 1, 1.5, 2 and 3 kHz in MS patients, suggesting a precocious subtle cochlear damage. Finally, non-significant correlations have been found between auditory parameters and clinical data.
Conclusions: This study provides the evidence for a subclinical cochlear impairment in untreated RR-MS patients with no brainstem demyelinated plaques, compared to age and sex-matched controls. The concomitant detectable dysfunction of the outer hair cells by OAEs may represent an early and temporary sign of hearing damage in MS, providing a powerful tool for an initial diagnosis, for monitoring the disease course and for detecting therapeutic response.
Disclosure: Dr. Maria Albanese received honoraria for travelling from Novartis, Teva, Merck Serono, Almirall, Biogen. She was involved as a sub-investigator for clinical trials on behalf of Novartis, Merck Serono, Teva, Bayer Schering, Sanofi-aventis, Biogen Idec, Roche.
The other authors declare that they have no competing and conflicting interests.
They did not receive funding for the project.

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