Intrathecal oligoclonal IgG synthesis is associated with retinal axonal loss in early diagnosed relapsing remitting multiple sclerosis
Author(s): ,
C.G. Chisari
Affiliations:
GF Ingrassia, University of Catania, Catania, Italy
,
E. D`Amico
Affiliations:
GF Ingrassia, University of Catania, Catania, Italy
,
A. Zanghì
Affiliations:
GF Ingrassia, University of Catania, Catania, Italy
,
S. Lo Fermo
Affiliations:
GF Ingrassia, University of Catania, Catania, Italy
,
M. Zappia
Affiliations:
GF Ingrassia, University of Catania, Catania, Italy
F. Patti
Affiliations:
GF Ingrassia, University of Catania, Catania, Italy
ECTRIMS Online Library. Chisari C. Oct 12, 2018; 228880; P1039
Clara Chisari
Clara Chisari
Contributions
Abstract

Abstract: P1039

Type: Poster Sessions

Abstract Category: Clinical aspects of MS - Neuro-ophthalmology

Introduction: intrathecal synthesis of oligoclonal bands (OCB) in multiple sclerosis (MS) is associated with brain atrophy. Thinning of retinal layer, measured by Optical Coherence Tomography (OCT), is a well-documented structural marker of axonal loss in MS.
Objective: to investigate whether the presence of OCB associates with retinal thinning in early stages of MS.
Aim: to assess early biomarkers of neurodegeneration in relapsing remitting MS (RRMS).
Methods: this cross-sectional study screened all patients with diagnosis of RRMS, referring to the Centre of the University of Catania in the period between 1st January 2014 to 30th December 2017. Patients with progressive MS, acute optic neuritis or evidence of optic disc swelling were excluded. At time of diagnosis, we collected demographical and clinical data. Retinal evaluation, assessed by OCT (Cyrrus5000), included the following measurements for right eye (RE) and left eye (LE): retinal nerve fiber layer (RNFL), single sector layer, ganglional cell layer (GCL).
Results: we enrolled 134 RRMS patients, 93 women (69.4%), mean age 44.2±15.6. Patients were divided in two groups: OCB+ (92; 68.5%) and OCB− (42; 31.3%) according to the presence or not of OCB, respectively. We found no difference in terms of clinical and demographical data between the groups. RRMS with OCB+ showed thinner RNFL (98.1±6.5 vs 101.5±5.4µm, p< 0.01 in RE; 98.3±5.3 vs 101.5±4.7µm, p< 0.01 in LE) and GCL (70.7±11.4 vs 77.7±7.2µm, p< 0.05 in RE; 73.3±5.7 vs 77.3±5.2µm in LE, p< 0.05) than RRMS with OCB-.
Conclusions: RRMS with OCB+ showed thinner RNFL and GCL. Our findings may suggest as the presence of OCB and retinal thickness at the time of diagnosis may be useful markers of neurodegeneration.
Disclosure: Clara G Chisari: nothing to declare in relation to this work
Emanuele D´Amico: nothing to declare in relation to this work
Aurora Zanghì: nothing to declare in relation to this work
Salvatore Lo Fermo: nothing to declare in relation to this work
Mario Zappia: nothing to declare in relation to this work
Francesco Patti: nothing to declare in relation to this work

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