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Tissue volume dependent retinal blood perfusion in patients with multiple sclerosis
Author(s): ,
J. Wang
Affiliations:
Bascom Palmer Eye Institute, University of Miami, Miami
,
Y. Liu
Affiliations:
Bascom Palmer Eye Institute, University of Miami, MIAMI, FL, United States; Department of Ophthalmology, Third Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, China
,
S. Delgado
Affiliations:
Department of Neurology, MS Center of Excellence, University of Miami School of Medicine, Miami, FL, United States
,
J. Hernandez
Affiliations:
Department of Neurology, MS Center of Excellence, University of Miami School of Medicine, Miami, FL, United States
,
Z. Duan
Affiliations:
Bascom Palmer Eye Institute, University of Miami, MIAMI, FL, United States; Zhongshan Ophthalmic Centre, Sun Yat-sen University, Guangzhou, China
H. Jiang
Affiliations:
Bascom Palmer Eye Institute, University of Miami, MIAMI, FL, United States; Department of Neurology, MS Center of Excellence, University of Miami School of Medicine, Miami, FL, United States
ECTRIMS Online Library. Wang J.
Oct 12, 2018; 228884
Jianhua Wang
Jianhua Wang
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Abstract: P1043

Type: Poster Sessions

Abstract Category: Clinical aspects of MS - Neuro-ophthalmology

Purpose: To determine tissue perfusion in the retina of patients with relapsing remitting multiple sclerosis (RRMS).
Methods: Twenty-six RRMS (age 39 ± 12 yrs, 12 females and 14 males) patients and 26 normal controls (age 41 ± 14 yrs, 14 Females and 12 males) were recruited. A retinal function imager was used to measure the retinal blood flow supplying the macular area (2.5 mm in diameter centered on the fovea). Tissue volumetric data of the macula in the same area was obtained by optical coherence tomography from the inner limiting membrane to outer nuclear layer. Perfusion was calculated as the flow dived by the corresponding tissue volume.
Results: The averaged macular tissue perfusion was 2.77 ± 0.48 nl/s/mm3 in MS, which was significantly lower from 3.87 ± 3.87 nl/s/mm3 in controls (p < 0.01), reflecting a decrease of 29%. The total macular flow volume was 2.49 ± 0.32 nl/s in MS, which was 36% lower flow from 3.90 ± 1.20 nl/s in controls (p< 0.01).
Conclusions: Our study has shown significant retinal hypoperfusion in patients with RRMS for the first time, indicating reduced retinal metabolic activity in MS.
Disclosure: Jianhua Wang: nothing to disclose
Yi Liu: nothing to disclose
Silvia Delgado: nothing to disclose
Jeffery Hernandez: nothing to disclose
Zhengyu Duan: nothing to disclose
Hong Jiang: nothing to disclose

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