Save
Cognitive-motor interference in multiple sclerosis and its relation to cognitive and motor impairments
Author(s): ,
P. Althoff
Affiliations:
Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Neurocure Cluster of Excellence, NeuroCure Clinical Research Center, Berlin
,
L. Schäfer
Affiliations:
Institut für Neuroimmunologie und MS (inims), Universitätsklinikum Hamburg-Eppendorf (UKE), Hamburg
,
F. Rosenthal
Affiliations:
Institut für Neuroimmunologie und MS (inims), Universitätsklinikum Hamburg-Eppendorf (UKE), Hamburg
,
B. King
Affiliations:
Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Neurocure Cluster of Excellence, NeuroCure Clinical Research Center, Berlin
,
D. Drebinger
Affiliations:
Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Neurocure Cluster of Excellence, NeuroCure Clinical Research Center, Berlin
,
F.C. Oertel
Affiliations:
Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Neurocure Cluster of Excellence, NeuroCure Clinical Research Center, Berlin
,
N. Ayadi
Affiliations:
Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Neurocure Cluster of Excellence, NeuroCure Clinical Research Center, Berlin
,
K. Otte
Affiliations:
Motognosis UG
,
R.M. Gieß
Affiliations:
Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Neurocure Cluster of Excellence, NeuroCure Clinical Research Center, Berlin
,
J. Bellmann-Strobl
Affiliations:
Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Neurocure Cluster of Excellence, NeuroCure Clinical Research Center, Berlin; Experimental and Clinical Research Center, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Insti
,
C. Heesen
Affiliations:
Institut für Neuroimmunologie und MS (inims), Universitätsklinikum Hamburg-Eppendorf (UKE), Hamburg
,
F. Paul
Affiliations:
Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Neurocure Cluster of Excellence, NeuroCure Clinical Research Center, Berlin; Experimental and Clinical Research Center, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Insti
,
A.U. Brandt
Affiliations:
Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Neurocure Cluster of Excellence, NeuroCure Clinical Research Center, Berlin
,
J.-P. Stellmann
Affiliations:
Institut für Neuroimmunologie und MS (inims), Universitätsklinikum Hamburg-Eppendorf (UKE), Hamburg
,
T. Schmitz-Hübsch
Affiliations:
Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Neurocure Cluster of Excellence, NeuroCure Clinical Research Center, Berlin
L. Rasche
Affiliations:
Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Neurocure Cluster of Excellence, NeuroCure Clinical Research Center, Berlin
ECTRIMS Online Library. Althoff P. Oct 12, 2018; 228999
Patrik Althoff
Patrik Althoff
Login now to access Regular content available to all registered users.

You may also access this content "anytime, anywhere" with the Free MULTILEARNING App for iOS and Android
Abstract
Discussion Forum (0)
Rate & Comment (0)

Abstract: P1159

Type: Poster Sessions

Abstract Category: Pathology and pathogenesis of MS - Neuropsychology

Introduction: Multiple Sclerosis (MS) may manifest with motor as well as cognitive dysfunctions. The dual-task (DT) phenomenon describes interference of performance in both modalities when executed simultaneously. Several studies of DT in MS demonstrated a decreased motor performance with concurrent cognitive task, yet there are few examining the opposite interaction.
Objectives: To describe cognitive-motor interference in static posturography in MS and explore associations of test performance with cognitive and motor dysfunction.
Methods: Static posturography was done in 62 people with MS (EDSS 0 - 6) and 20 healthy participants (HC) using infrared sensors (Microsoft Kinect V2, MotognosisLabs 1.0). Postural control was described by mean angular sway velocity during 20 sec (MSV3D (°/sec)) in four conditions: 1) eyes open (EO), 2) eyes closed (EC), 3) during serial subtraction of three with EO and 4) EC. Changes of performance with dual task were described as DT ratio with value >1 denoting worsening of performance with DT: cognitive DT ratio of calculation steps (conditions 3 to 4) and motor DT ratio of MSV3D (3 to 1). Romberg ratio (RR) for MSV3D was calculated for single task (ST) (2 to 1) and DT (4 to 3). Motor and cognitive DT ratios were correlated in MS with measures of balance (MSV3D ST EC) and cognitive dysfunction (symbol digit modalities test, SDMT).
Results: HC had a RR ST of 1.42 that decreased towards 1 in DT (1.05), a motor DT ratio of 2.14 and a cognitive DT ratio of 1.35. MS patients had a RR ST of 1.96 that decreased to 1.14 in DT, a motor DT ratio of 2.21 and a cognitive DT ratio of 1.22. Balance impairment (MSV3D ST EC) in MS was associated with higher RR ST (ρ=0.655) and cognitive DT ratio (ρ=0.328). Cognitive impairment (SDMT) was associated with higher DT ratio (ρ=-0.443), i.e. slowing of calculation without visual control, but not with motor performance during the task.
Conclusions: Our description revealed strikingly similar behaviour in HC and MS. Closing eyes as well as cognitive DT lead to increase of sway in both groups with no further increase when combined, yet at the cost of cognitive task performance (cognitive DT ratio >1). This points to a physiological priority of motor performance under challenging conditions that is preserved in MS at group level and even more pronounced with balance impairment. In contrast, cognitive processing speed in MS seems related to only cognitive but not motor performance in this paradigm.
Disclosure: P. Althoff, L. Schäfer, F. Rosenthal, B. King, D. Drebinger, F. C. Oertel, N. Ayadi, R. M. Gieß, L. Rasche: nothing to disclose
K. Otte is a shareholder of Motognosis
J. Bellmann-Strobl has received travel grants and speaking fees from Bayer Healthcare, Biogen Idec, Merck Serono, sanofi-aventis/Genzyme, Teva Pharmaceuticals, and Novartis.
C. Heesen received speaker honoraria from Biogen, Merck Genzyme, and Novartis; is on the editorial board of the International Journal of MS Care; and received research support from Genzyme, Biogen, Roche, Novartis, Merck, Sanofi-Aventis, and the German Ministry of Research.
F. Paul serves on the scientific advisory board for Novartis; received speaker honoraria and travel funding from Bayer, Novartis, Biogen Idec, Teva, Sanofi-Aventis/Genzyme, Merck Serono, Alexion, Chugai, MedImmune, and Shire; is an academic editor for PLoS ONE; is an associate editor for Neurology® Neuroimmunology & Neuroinflammation; consulted for SanofiGenzyme, Biogen Idec, MedImmune, Shire, and Alexion; and received research support from Bayer, Novartis, Biogen Idec, Teva, Sanofi-Aventis/Genzyme, Alexion, Merck Serono, German Research Council, Werth Stiftung of the City of Cologne, German Ministry of Education and Research, Arthur Arnstein Stiftung Berlin, EU FP7 Framework Program, Arthur Arnstein Foundation Berlin, Guthy Jackson Charitable Foundation, and National Multiple Sclerosis of the USA.
A. U. Brandt is cofounder and shareholder of Motognosis and Nocturne. He is named as inventor on several patent applications regarding MS serum biomarkers, OCT image analysis and perceptive visual computing.
J.-P. Stellmann receives research funding from Deutsche Forschungsgemeinschaft and reports grants from Biogen and Genzyme.
T. Schmitz-Hübsch received research grants from Ipsen Pharma and speaker honoraria from Rölke pharma.

Code of conduct/disclaimer available in General Terms & Conditions
Anonymous User Privacy Preferences

Strictly Necessary Cookies (Always Active)

MULTILEARNING platforms and tools hereinafter referred as “MLG SOFTWARE” are provided to you as pure educational platforms/services requiring cookies to operate. In the case of the MLG SOFTWARE, cookies are essential for the Platform to function properly for the provision of education. If these cookies are disabled, a large subset of the functionality provided by the Platform will either be unavailable or cease to work as expected. The MLG SOFTWARE do not capture non-essential activities such as menu items and listings you click on or pages viewed.


Performance Cookies

Performance cookies are used to analyse how visitors use a website in order to provide a better user experience.



Google Analytics is used for user behavior tracking/reporting. Google Analytics works in parallel and independently from MLG’s features. Google Analytics relies on cookies and these cookies can be used by Google to track users across different platforms/services.


Save Settings