Pathologic evidence for disease heterogeneity
ECTRIMS Online Library. Brück W. Oct 12, 2018; 232043; 290
Prof. Wolfgang Brück
Prof. Wolfgang Brück
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Abstract: 290

Type: Scientific Session

Abstract Category: N/A

Multiple sclerosis (MS) belongs to the spectrum of inflammatory demyelinating disorders of the central nervous system including classic MS, acute disseminated encephalomyelitis (ADEM), neuromyelitis optica spectrum disorders (NMOSD) and anti-MOG antibody associated demyelination.
The present lecture summarizes the characteristics of the different disease entities mentioned above and their pathological commonalities and differences. MS reveals extensive white and grey matter demyelination as well as involvement of the noral appearing brain tissue. NMOSD is a primary astrocyte disorder with secondary demyelination. Anti-MOG antibody associated demyelination is heterogeneous and shows features of ADEM-like perivascular demyelination and confluent MS-like demyelination.
In summary, the major pathological differences between the different inflammatory demyelinating disease entities in different disease stages are described in detail.
Disclosure: Wolfgang Brück has received honoraria for lectures by Bayer Vital, Biogen, Merck Serono, Teva, Genzyme, Roche and Novartis. He is a member of scientific advisory boards for Teva, Biogen, Novartis, MedDay, Celgene and Genzyme. Wolfgang Brück receives research support from Teva, Biogen, Genzyme, MedDay and Novartis.

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