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Clinical significance
ECTRIMS Online Library. Chard D. Oct 12, 2018; 232061
Declan Chard
Declan Chard
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Abstract: 308

Type: Educational Session

Abstract Category: N/A

Neurological and cognitive outcomes in people with multiple sclerosis (MS) are diverse, and have proven difficult to explain based on magnetic resonance imaging (MRI) visible pathology. At a whole brain and regional level, measures such as white matter lesions loads in part explain clinical outcomes, but a substantial mismatch has been observed, described as a clinico-radiological paradox. Recognising that the brain functions through neural networks, with the advent of MRI techniques that allow us to assess structural and functional connectivity in life, studies have explored the effects MS pathology has on the structural and functional integrity of networks, and their capacity for compensation and adaptation. These have shown that brain networks respond dynamically to MS pathology, that structural and functional changes need not entirely mirror each other, and that they may both contribute towards functional outcomes. In this session, we will consider the clinical significance of structural and functional network changes in MS, and their potential relevance for targeting treatments and assessing efficacy in trials.
Disclosure: Declan Chard has received honoraria (paid to his employer) from Excemed for faculty-led education work; had meeting expenses funded by Merck, MS Trust, National MS Society, Novartis, Société des Neurosciences and Swiss MS Society; and has previously held stock in GlaxoSmithKline. He has received research funding from the International Progressive MS Alliance, the MS Society of Great Britain and Northern Ireland, and the National Institute for Health Research (NIHR) University College London Hospitals (UCLH) Biomedical Research Centre.

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