Brain magnetic resonance imaging features in MS and neuromyelitis optica spectrum disorders (NMOSD) patients with or without aquaporin-4 antibody in a Latin American population
ECTRIMS Online Library. Rojas J. 09/13/19; 278303; P1101
Juan Ignacio Rojas
Juan Ignacio Rojas
Contributions
Abstract

Abstract: P1101

Type: Poster Sessions

Abstract Category: Clinical aspects of MS - MS Variants

F. Silveira1, F. Sanchez1, V. Daccach Marques2, I. Soto de Castillo3, V. Tkachuk4, A. Caride5, M.C. Castillo3, E. Cristiano1, C. de Aquino Cruz6, G. Braga Diégues6, A.C. dos Santos2, C. Lavigne Moreira2, P.A. Lopez5, L. Patrucco1, O. Molina3, J.P. Pettinicchi5, E. Carnero Contentti5, J.I. Rojas1

1Centro de Esclerosis Multiple de Buenos Aires, Buenos Aires, Argentina, 2Department of Neurosciences and Behavioral Sciences, Hospital das Clínicas, Ribeirão Preto Medical School, University of de São Paulo, São Paulo, Brazil, Sao Paulo, Brazil, 3Neurology Department, Hospital Universitario de Maracaibo, Maracaibo, Venezuela, Maracaibo, 4Neuroimmunology Unit, Department of Neurology, Hospital de Clínicas 'José de San Martín', 5Neuroimmunology Unit, Department of Neuroscience, Hospital Alemán, Buenos Aires, Argentina, Buenos Aires, Argentina, 6Department of Neurosciences and Behavioral Sciences, Hospital das Clínicas, Ribeirão Preto Medical School, University of de São Paulo, Sao Paulo, Brazil

There is scarce evidence comparing the behaviour in the magnetic resonance (MR) between positive and negative aquaporin-4 antibody neuromyelitis optica spectrum disorders (P-NMOSD and N-NMOSD respectively and multiple sclerosis (MS) patients. The aim of the study was to describe and compare the MR features through a quantitative and qualitative analysis, between P-NMOSD; N-NMOSD and MS patients in a cohort from Latin American (LATAM).
Methods: We retrospectively reviewed the MR and the medical records of NMOSD defined by the 2015 validated diagnostic criteria and MS patients with at least 3 years of follow-up since disease onset (first symptom). We included patients from Argentina, Brazil and Venezuela. To be included, NMOSD patients must had AQP4-ab status measured by a cell-based assay (CBA). Brain MRs were obtained for each participant at disease onset and every 12 months for 3 years. Demographics, clinical and MR variables (brain volume lesions (BVL), whole brain (HB), deep grey matter volumes (DGMV), cortical thickness (CT), and year percentage of brain volume change (PBVC)) was analyzed and compared between groups (P-NMOSD; N-NMOSD and MS).
Results
: We included 24 P-NMOSD, 15 N-NMOSD and 35 MS patients. No differences in age, gender and follow-up time was observed between groups. No differences were also observed in quantitative and qualitative MR variables between P-NMOSD and N-NMOSD patients (BVL p=0.43, HB p= 0.32, DGMV p=0.28, CT p=0.12 and PBVC p=0.45 as well as lesion distribution). A significant reduction in cortical thickness (p=0.001), HB (p=0.0012) and PBVC (p= 0.01) was observed in MS compared with NMOSD patients.
Conclusions: Significant differences were observed in MRI between MS and NMOSD patients, however no quantitative neither qualitative difference were observed between P-NMOSD and N-NMOSD patients being impossible to differentiate this condition by means of the MRI.
Disclosure: Authors declare no conflict of interest

Abstract: P1101

Type: Poster Sessions

Abstract Category: Clinical aspects of MS - MS Variants

F. Silveira1, F. Sanchez1, V. Daccach Marques2, I. Soto de Castillo3, V. Tkachuk4, A. Caride5, M.C. Castillo3, E. Cristiano1, C. de Aquino Cruz6, G. Braga Diégues6, A.C. dos Santos2, C. Lavigne Moreira2, P.A. Lopez5, L. Patrucco1, O. Molina3, J.P. Pettinicchi5, E. Carnero Contentti5, J.I. Rojas1

1Centro de Esclerosis Multiple de Buenos Aires, Buenos Aires, Argentina, 2Department of Neurosciences and Behavioral Sciences, Hospital das Clínicas, Ribeirão Preto Medical School, University of de São Paulo, São Paulo, Brazil, Sao Paulo, Brazil, 3Neurology Department, Hospital Universitario de Maracaibo, Maracaibo, Venezuela, Maracaibo, 4Neuroimmunology Unit, Department of Neurology, Hospital de Clínicas 'José de San Martín', 5Neuroimmunology Unit, Department of Neuroscience, Hospital Alemán, Buenos Aires, Argentina, Buenos Aires, Argentina, 6Department of Neurosciences and Behavioral Sciences, Hospital das Clínicas, Ribeirão Preto Medical School, University of de São Paulo, Sao Paulo, Brazil

There is scarce evidence comparing the behaviour in the magnetic resonance (MR) between positive and negative aquaporin-4 antibody neuromyelitis optica spectrum disorders (P-NMOSD and N-NMOSD respectively and multiple sclerosis (MS) patients. The aim of the study was to describe and compare the MR features through a quantitative and qualitative analysis, between P-NMOSD; N-NMOSD and MS patients in a cohort from Latin American (LATAM).
Methods: We retrospectively reviewed the MR and the medical records of NMOSD defined by the 2015 validated diagnostic criteria and MS patients with at least 3 years of follow-up since disease onset (first symptom). We included patients from Argentina, Brazil and Venezuela. To be included, NMOSD patients must had AQP4-ab status measured by a cell-based assay (CBA). Brain MRs were obtained for each participant at disease onset and every 12 months for 3 years. Demographics, clinical and MR variables (brain volume lesions (BVL), whole brain (HB), deep grey matter volumes (DGMV), cortical thickness (CT), and year percentage of brain volume change (PBVC)) was analyzed and compared between groups (P-NMOSD; N-NMOSD and MS).
Results
: We included 24 P-NMOSD, 15 N-NMOSD and 35 MS patients. No differences in age, gender and follow-up time was observed between groups. No differences were also observed in quantitative and qualitative MR variables between P-NMOSD and N-NMOSD patients (BVL p=0.43, HB p= 0.32, DGMV p=0.28, CT p=0.12 and PBVC p=0.45 as well as lesion distribution). A significant reduction in cortical thickness (p=0.001), HB (p=0.0012) and PBVC (p= 0.01) was observed in MS compared with NMOSD patients.
Conclusions: Significant differences were observed in MRI between MS and NMOSD patients, however no quantitative neither qualitative difference were observed between P-NMOSD and N-NMOSD patients being impossible to differentiate this condition by means of the MRI.
Disclosure: Authors declare no conflict of interest

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