Positive history of diseases and risk factors in Neuromyelitis optica spectrum disorder: a case-control study
ECTRIMS Online Library. Eskandarieh S. 09/13/19; 278335; P1133
Sharareh Eskandarieh
Sharareh Eskandarieh
Contributions
Abstract

Abstract: P1133

Type: Poster Sessions

Abstract Category: Clinical aspects of MS - Epidemiology

S. Eskandarieh1, A.N. Moghadasi1, I. Abdollahpour2, A.R. Azimi1, M.A. Sahraian1

1Multiple Sclerosis Research Center, Neuroscience Institute, Tehran University of Medical Sciences, 2Department of Epidemiology and Biostatistics, School of Public Health, Arak University of Medical Sciences, Tehran, Islamic Republic of Iran

Introduction: Neuromyelitis optica spectrum disorder (NMOSD) is an autoimmune inflammatory disease with limited identified risk factors.
The present study aimed to discover the potential risk factors associated with medical history of diseases among people with NMOSD.
Method: A case-control study was conducted in 2016 in Tehran, Iran. This study was performed amongst NMOSD patients with NMO-IgG positivity status diagnosis based on the international 2015 consensus criteria. Controls were matched on sex among residents population of Tehran.
A structured questionnaire was designed in the MS research center of Tehran University to assess potential risk factors of NMOSD regarding exposure for different diseases diagnosed by a physician and severe head trauma leading to vomiting, loss of consciousness or bleeding. Logistic regression was used to estimate odds ratio (OR) at 95% confidence intervals (CI ) via SPSS 23.
Results: A total of 50 patients with NMOSD and 201 healthy controls registered in the survey.
Female to male ratio was 7:1.
In comparison with control group, in NMOSD cases, the OR for person who had history of depression )OR = 2.91; 95% CI 1.83, 4.64), migraine (OR = 1.88; 95% CI 1.08, 3.22), rheumatoid arthritis (OR = 2.12; 95% CI 1.02, 4.41), Ulcerative colitis (OR = 6.13; 95% CI 1.01, 37.34), Kidney failure (OR = 4.87; 95% CI 2.32, 10.25) and severe head trauma (OR = 7.68; 95% CI 4.71, 12.52) has association with an increased risk of NMOSD. There was no relationship between lupus, hypothyroid, hyperthyroid and type-1 diabetes with NMOSD risk factor.
Conclusion: A positive history of disease and comorbidity profile highlights the importance of environmental risk factors in NMOSD pathogenesis.
Having positive history of depression, migraine, infectious mononucleosis, rheumatoid arthritis, Ulcerative colitis, kidney failure and head trauma are considerably correlated with an increase in NMOSD.
Disclosure:
S Eskandarieh: nothing to disclose
A.N. Moghadasi: nothing to disclose
I Abdollahpour: nothing to disclose
A.R. Azimi: nothing to disclose
M.A. Sahraian: nothing to disclose

Abstract: P1133

Type: Poster Sessions

Abstract Category: Clinical aspects of MS - Epidemiology

S. Eskandarieh1, A.N. Moghadasi1, I. Abdollahpour2, A.R. Azimi1, M.A. Sahraian1

1Multiple Sclerosis Research Center, Neuroscience Institute, Tehran University of Medical Sciences, 2Department of Epidemiology and Biostatistics, School of Public Health, Arak University of Medical Sciences, Tehran, Islamic Republic of Iran

Introduction: Neuromyelitis optica spectrum disorder (NMOSD) is an autoimmune inflammatory disease with limited identified risk factors.
The present study aimed to discover the potential risk factors associated with medical history of diseases among people with NMOSD.
Method: A case-control study was conducted in 2016 in Tehran, Iran. This study was performed amongst NMOSD patients with NMO-IgG positivity status diagnosis based on the international 2015 consensus criteria. Controls were matched on sex among residents population of Tehran.
A structured questionnaire was designed in the MS research center of Tehran University to assess potential risk factors of NMOSD regarding exposure for different diseases diagnosed by a physician and severe head trauma leading to vomiting, loss of consciousness or bleeding. Logistic regression was used to estimate odds ratio (OR) at 95% confidence intervals (CI ) via SPSS 23.
Results: A total of 50 patients with NMOSD and 201 healthy controls registered in the survey.
Female to male ratio was 7:1.
In comparison with control group, in NMOSD cases, the OR for person who had history of depression )OR = 2.91; 95% CI 1.83, 4.64), migraine (OR = 1.88; 95% CI 1.08, 3.22), rheumatoid arthritis (OR = 2.12; 95% CI 1.02, 4.41), Ulcerative colitis (OR = 6.13; 95% CI 1.01, 37.34), Kidney failure (OR = 4.87; 95% CI 2.32, 10.25) and severe head trauma (OR = 7.68; 95% CI 4.71, 12.52) has association with an increased risk of NMOSD. There was no relationship between lupus, hypothyroid, hyperthyroid and type-1 diabetes with NMOSD risk factor.
Conclusion: A positive history of disease and comorbidity profile highlights the importance of environmental risk factors in NMOSD pathogenesis.
Having positive history of depression, migraine, infectious mononucleosis, rheumatoid arthritis, Ulcerative colitis, kidney failure and head trauma are considerably correlated with an increase in NMOSD.
Disclosure:
S Eskandarieh: nothing to disclose
A.N. Moghadasi: nothing to disclose
I Abdollahpour: nothing to disclose
A.R. Azimi: nothing to disclose
M.A. Sahraian: nothing to disclose

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