Disruption of a potential emotional salience network is associated with lower depression in multiple sclerosis
ECTRIMS Online Library. Fuchs T. 09/13/19; 278383; P1181
Tom Fuchs
Tom Fuchs
Contributions
Abstract

Abstract: P1181

Type: Poster Sessions

Abstract Category: Clinical aspects of MS - Patient reported outcomes

T. Fuchs, C. Vaughn, R. Benedict, B. Weinstock-Guttman, N. Bergsland, D. Jakimovski, D. Ramasamy, R. Zivadinov, M. Dwyer

University at Buffalo, State University of New York, Buffalo, NY, United States

Background: Localized white matter (WM) damage between gray matter regions including the amygdala, insula, and surrounding structures correlates negatively with self-report fatigue in people with multiple sclerosis (PwMS). This network may comprise a generalizable emotional salience network and its disconnection might therefore also be associated with depression.
Methods: We studied 137 PwMS who completed MRI and Beck Depression Inventory-fast screen (BDI-FS). For these individuals, we calculated the mean proportion of WM tracts disrupted between GM region-pairs included in the proposed emotional salience network.
Results: Study participants had a mean (SD) age and disease duration of 53.2 (11.6) and 20.6 (10.6) years, respectively. Their median (Interquartile range [IQR]) EDSS and BDI-FS scores were 3.0 (4.0) and 2.0 (4.0), respectively. We found that increased disruption within the proposed emotional salience network predicts lower self-report depression (β=-0.288) after accounting for age, sex, T2-lesion volume, gray matter volume and WM volume (ΔR2=0.035, p-value=0.031).
Conclusion: We suggest that the identified network may be a generalizable emotional salience network which corresponds to the recognition of negative emotional valence, and that damage to this network can paradoxically protect against negative emotional perception.
Disclosure: Tom Fuchs, Caila Vaugh, Dejan Jakimovski, Niels Bergsland, and Deepa Ramasamy have nothing to disclose.
Bianca Weinstock- Guttman received honoraria as a speaker and as a consultant for Biogen, EMD Serono, Novartis, Genentech and Mallickrodt. Dr Weinstock-Guttman received research funds from same agencies.
Michael G. Dwyer has received consultant fees from Claret Medical and EMD Serono.
Ralph H. B. Benedict has received research support from Accorda, Novartis, Genzyme, Biogen Idec, and Mallinkrodt, and is on the speakers' bureau for EMD Serono, and consults for Biogen Idec, Genentech, Roche, Sanofi/Genzyme, Takeda, NeuroCog Trials, and Novartis. Dr. Benedict also receives royalties for Psychological Assessment Resources.
Robert Zivadinov received personal compensation from EMD Serono, Genzyme-Sanofi, Claret Medical, Celgene and Novartis for speaking and consultant fees. He received financial support for research activities from Genzyme-Sanofi, Novartis, Celgene, Claret Medical, Intekrin-Coherus, Protembis and Qunitiles/IMS

Abstract: P1181

Type: Poster Sessions

Abstract Category: Clinical aspects of MS - Patient reported outcomes

T. Fuchs, C. Vaughn, R. Benedict, B. Weinstock-Guttman, N. Bergsland, D. Jakimovski, D. Ramasamy, R. Zivadinov, M. Dwyer

University at Buffalo, State University of New York, Buffalo, NY, United States

Background: Localized white matter (WM) damage between gray matter regions including the amygdala, insula, and surrounding structures correlates negatively with self-report fatigue in people with multiple sclerosis (PwMS). This network may comprise a generalizable emotional salience network and its disconnection might therefore also be associated with depression.
Methods: We studied 137 PwMS who completed MRI and Beck Depression Inventory-fast screen (BDI-FS). For these individuals, we calculated the mean proportion of WM tracts disrupted between GM region-pairs included in the proposed emotional salience network.
Results: Study participants had a mean (SD) age and disease duration of 53.2 (11.6) and 20.6 (10.6) years, respectively. Their median (Interquartile range [IQR]) EDSS and BDI-FS scores were 3.0 (4.0) and 2.0 (4.0), respectively. We found that increased disruption within the proposed emotional salience network predicts lower self-report depression (β=-0.288) after accounting for age, sex, T2-lesion volume, gray matter volume and WM volume (ΔR2=0.035, p-value=0.031).
Conclusion: We suggest that the identified network may be a generalizable emotional salience network which corresponds to the recognition of negative emotional valence, and that damage to this network can paradoxically protect against negative emotional perception.
Disclosure: Tom Fuchs, Caila Vaugh, Dejan Jakimovski, Niels Bergsland, and Deepa Ramasamy have nothing to disclose.
Bianca Weinstock- Guttman received honoraria as a speaker and as a consultant for Biogen, EMD Serono, Novartis, Genentech and Mallickrodt. Dr Weinstock-Guttman received research funds from same agencies.
Michael G. Dwyer has received consultant fees from Claret Medical and EMD Serono.
Ralph H. B. Benedict has received research support from Accorda, Novartis, Genzyme, Biogen Idec, and Mallinkrodt, and is on the speakers' bureau for EMD Serono, and consults for Biogen Idec, Genentech, Roche, Sanofi/Genzyme, Takeda, NeuroCog Trials, and Novartis. Dr. Benedict also receives royalties for Psychological Assessment Resources.
Robert Zivadinov received personal compensation from EMD Serono, Genzyme-Sanofi, Claret Medical, Celgene and Novartis for speaking and consultant fees. He received financial support for research activities from Genzyme-Sanofi, Novartis, Celgene, Claret Medical, Intekrin-Coherus, Protembis and Qunitiles/IMS

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