Cognitive reserve mediates the association between cognition and white matter microstructural damage in early MS
ECTRIMS Online Library. Vinciguerra C. 09/13/19; 278464; P1261
Claudia Vinciguerra
Claudia Vinciguerra
Contributions
Abstract

Abstract: P1261

Type: Poster Sessions

Abstract Category: Pathology and pathogenesis of MS - MRI and PET

C. Vinciguerra1, A. Giorgio1, J. Zhang1, A. Signori2, R. Tappa Brocci1, L. Pastò3, C. Niccolai3, M.L. Stromillo1, M. Mortilla4, M.P. Sormani2, M.P. Amato3, N. De Sefano1

1Department of Medicine, Surgery and Neuroscience, University of Siena, Siena, 2Department of Health Sciences-Section of Biostatistics, University of Genoa, Genoa, 3Department of NEUROFARBA, Neuroscience Division, University of Florence, 4Anna Meyer Children's University Hospital, Florence, Italy

Introduction: Cognitive reserve (CR) in MS is thought to play a protective role on cognition, allowing coping better with brain damage. Previous studies mostly investigated the relationship of CR with brain atrophy but not with white matter (WM) microstructural damage
Objective: To explore the relevance of CR on the association between cognitive impairment (CI) and WM microstructural damage in early MS.
Methods: Relapsing remitting (RR) MS patients (n=56, 76% females;, age: 42.5±10 years, MS duration: 9.1±6.1 years, median EDSS: 1, CI in 35.7%) underwent a 3T MRI examination to compute WM microstructural damage (through Tract-Based Spatial Statistics of DTI data). Cognition was evaluated with Rao's Brief Repeatable Battery (BRB) and CR with an index (CRI) combining educational level, current leisure activities and intellectual quotient. Voxelwie analyses were performed with non parametric permutation test (p< 0.05, corrected).
Results: Cognitive tests showed that in the group of RR-MS patients worse symbol digit modalities test (SDMT) performance correlated with lower CRI (r=0.43, p< 0.001), higher T2-lesion volume (r=-0.34, p=0.011), lower fractional anisotropy (FA) in clusters of corona radiata, optic radiation, WM of planum temporale (r=0.43, p< 0.001), higher mean diffusivity (MD) in clusters of callosal body and WM of inferior frontal gyrus (r=-0.46, p< 0.001) whereas no significant clusters were found for axial and radial diffusivity. Multivariate analysis, adjusted for age, EDSS and head size, showed that the best predictor of SDMT (R2=0.26) was MD (p=0.034). A mediation analysis showed that CRI explained 38% of the correlation between SDMT and MD and 32% of the correlation between SDMT and FA.
Conclusions: Measures of CR and information processing speed resulted associated with WM microstructural integrity. Higher CR may alleviate the impact of WM microstructural damage on CI even at relatively early MS stages.
Disclosure: Claudia Vinciguerra, Antonio Giorgio, Jian Zhang, Riccardo Tappa Brocci, Claudia Niccolai, Maria Laura Stromillo and Marzia Mortilla, have nothing to disclose.
Alessio Signori received teaching honoraria from Novartis.
Luisa Pastò received editorial grants by Sanofi-Genzyme, Novartis, received grant from Novartis and speaker's honoraria from Teva, Biogen and served on scientific advisory board from Merk.
Maria Pia Sormanni has received consulting fees from Biogen, TEVA, Novartis, Merck Serono, Genzyme, Roche, GeNeuro, Medday, Celgene, Actelion
Maria Pia Amato is member ofAdvisory Boards for Biogen, Merck, Teva, Novartis, Sanofi Aventis, Genzyme, Almirall and Roche. She received honoraria for speaking from Biogen, Merck, Novartis, Teva, Genzyme, Almirall and Sanofi Aventis. She is member of Editorial Board and Associate Editor of BMC Neurology Member of the Editorial Board of Multiple Sclerosis Journal research grants from Biogen, Merk, Bayer, Sanofi Aventis, Teva
Nicola De Stefano has received honoraria from Biogen-Idec, Genzyme, Merck Serono, Novartis, Roche and Teva for consulting services, speaking and travel support. He serves on advisory boards for Merck Serono, Novartis, Biogen-Idec, Roche, and Genzyme, he has received research grant support from the Italian MS Society.

Abstract: P1261

Type: Poster Sessions

Abstract Category: Pathology and pathogenesis of MS - MRI and PET

C. Vinciguerra1, A. Giorgio1, J. Zhang1, A. Signori2, R. Tappa Brocci1, L. Pastò3, C. Niccolai3, M.L. Stromillo1, M. Mortilla4, M.P. Sormani2, M.P. Amato3, N. De Sefano1

1Department of Medicine, Surgery and Neuroscience, University of Siena, Siena, 2Department of Health Sciences-Section of Biostatistics, University of Genoa, Genoa, 3Department of NEUROFARBA, Neuroscience Division, University of Florence, 4Anna Meyer Children's University Hospital, Florence, Italy

Introduction: Cognitive reserve (CR) in MS is thought to play a protective role on cognition, allowing coping better with brain damage. Previous studies mostly investigated the relationship of CR with brain atrophy but not with white matter (WM) microstructural damage
Objective: To explore the relevance of CR on the association between cognitive impairment (CI) and WM microstructural damage in early MS.
Methods: Relapsing remitting (RR) MS patients (n=56, 76% females;, age: 42.5±10 years, MS duration: 9.1±6.1 years, median EDSS: 1, CI in 35.7%) underwent a 3T MRI examination to compute WM microstructural damage (through Tract-Based Spatial Statistics of DTI data). Cognition was evaluated with Rao's Brief Repeatable Battery (BRB) and CR with an index (CRI) combining educational level, current leisure activities and intellectual quotient. Voxelwie analyses were performed with non parametric permutation test (p< 0.05, corrected).
Results: Cognitive tests showed that in the group of RR-MS patients worse symbol digit modalities test (SDMT) performance correlated with lower CRI (r=0.43, p< 0.001), higher T2-lesion volume (r=-0.34, p=0.011), lower fractional anisotropy (FA) in clusters of corona radiata, optic radiation, WM of planum temporale (r=0.43, p< 0.001), higher mean diffusivity (MD) in clusters of callosal body and WM of inferior frontal gyrus (r=-0.46, p< 0.001) whereas no significant clusters were found for axial and radial diffusivity. Multivariate analysis, adjusted for age, EDSS and head size, showed that the best predictor of SDMT (R2=0.26) was MD (p=0.034). A mediation analysis showed that CRI explained 38% of the correlation between SDMT and MD and 32% of the correlation between SDMT and FA.
Conclusions: Measures of CR and information processing speed resulted associated with WM microstructural integrity. Higher CR may alleviate the impact of WM microstructural damage on CI even at relatively early MS stages.
Disclosure: Claudia Vinciguerra, Antonio Giorgio, Jian Zhang, Riccardo Tappa Brocci, Claudia Niccolai, Maria Laura Stromillo and Marzia Mortilla, have nothing to disclose.
Alessio Signori received teaching honoraria from Novartis.
Luisa Pastò received editorial grants by Sanofi-Genzyme, Novartis, received grant from Novartis and speaker's honoraria from Teva, Biogen and served on scientific advisory board from Merk.
Maria Pia Sormanni has received consulting fees from Biogen, TEVA, Novartis, Merck Serono, Genzyme, Roche, GeNeuro, Medday, Celgene, Actelion
Maria Pia Amato is member ofAdvisory Boards for Biogen, Merck, Teva, Novartis, Sanofi Aventis, Genzyme, Almirall and Roche. She received honoraria for speaking from Biogen, Merck, Novartis, Teva, Genzyme, Almirall and Sanofi Aventis. She is member of Editorial Board and Associate Editor of BMC Neurology Member of the Editorial Board of Multiple Sclerosis Journal research grants from Biogen, Merk, Bayer, Sanofi Aventis, Teva
Nicola De Stefano has received honoraria from Biogen-Idec, Genzyme, Merck Serono, Novartis, Roche and Teva for consulting services, speaking and travel support. He serves on advisory boards for Merck Serono, Novartis, Biogen-Idec, Roche, and Genzyme, he has received research grant support from the Italian MS Society.

By clicking “Accept Terms & all Cookies” or by continuing to browse, you agree to the storing of third-party cookies on your device to enhance your user experience and agree to the user terms and conditions of this learning management system (LMS).

Cookie Settings
Accept Terms & all Cookies