Impacts of citrulline malate supplementation on the fatigue in multiple sclerosis
ECTRIMS Online Library. Maroufi N. 09/13/19; 278651; P1611
Negar Maroufi
Negar Maroufi
Contributions
Abstract

Abstract: P1611

Type: Poster Sessions

Abstract Category: Poster Session 3

A. Ghoreishy1, A. Khosravi2, S. Arash3, N. Maroufi1, M. Asadi-Khiavi4

1Department of Neurology, Zanjan University of Medical Science, Zanjan, 2Clinical Immunology Research Center, Zahedan University of Medical Science, Zahedan, 3Zanjan Applied Pharmacology Research Center, 4Department of Pharmacotherapy, Zanjan University of Medical Science, Zanjan, Islamic Republic of Iran

Multiple Sclerosis (MS) is a chronic inflammatory demyelinating disease of central nervous system and fatigue is one of the most common symptoms in multiple sclerosis.As a result, patient's daily affairs deteriorate obviously by fatigue. Citrulline Malate supplementation and Amantadin are two drugs that used for attenuating of fatigue./this study designed to evaluate Citrulline Malate utilization efficacy in MS patients./To investigate the impacts of Citrulline Malate on the fatigue in MS/In this double-blind randomized clinical trial a total number of 90 MS patients referring to neurology clinic who complain of fatigue were enrolled in study .The patients were randomly assigned into groups for at least one month therapy: Amantadin alone users as group 1, concomitant use of Amantadin and Citrulline Malate as group 2 and Citrulline Malate alone users as group 3. Patient´s fatigue intensity was measured using fatigue severity scale (FSS) questionnaire./ There were no statistically significant differences among groups regarding to age, sex, living place, and duration of MS disease as well as marital status and education levels of participants. Statistically significant diminish in the rates of the patients fatigue based on the Fatigue Severity Scale (FSS) were found among patients who used Citrulline Malate or concomitant users of Amantadin and Citrulline Malate in comparison with Amantadin alone users (P-value ˂ 0.0001)./According to our findings, Citrulline Malate possess a significant property for fatigue handling in MS patients .
Disclosure: The authors have no conflicts of intrest and no relevant financial relation with any organisation.

Abstract: P1611

Type: Poster Sessions

Abstract Category: Poster Session 3

A. Ghoreishy1, A. Khosravi2, S. Arash3, N. Maroufi1, M. Asadi-Khiavi4

1Department of Neurology, Zanjan University of Medical Science, Zanjan, 2Clinical Immunology Research Center, Zahedan University of Medical Science, Zahedan, 3Zanjan Applied Pharmacology Research Center, 4Department of Pharmacotherapy, Zanjan University of Medical Science, Zanjan, Islamic Republic of Iran

Multiple Sclerosis (MS) is a chronic inflammatory demyelinating disease of central nervous system and fatigue is one of the most common symptoms in multiple sclerosis.As a result, patient's daily affairs deteriorate obviously by fatigue. Citrulline Malate supplementation and Amantadin are two drugs that used for attenuating of fatigue./this study designed to evaluate Citrulline Malate utilization efficacy in MS patients./To investigate the impacts of Citrulline Malate on the fatigue in MS/In this double-blind randomized clinical trial a total number of 90 MS patients referring to neurology clinic who complain of fatigue were enrolled in study .The patients were randomly assigned into groups for at least one month therapy: Amantadin alone users as group 1, concomitant use of Amantadin and Citrulline Malate as group 2 and Citrulline Malate alone users as group 3. Patient´s fatigue intensity was measured using fatigue severity scale (FSS) questionnaire./ There were no statistically significant differences among groups regarding to age, sex, living place, and duration of MS disease as well as marital status and education levels of participants. Statistically significant diminish in the rates of the patients fatigue based on the Fatigue Severity Scale (FSS) were found among patients who used Citrulline Malate or concomitant users of Amantadin and Citrulline Malate in comparison with Amantadin alone users (P-value ˂ 0.0001)./According to our findings, Citrulline Malate possess a significant property for fatigue handling in MS patients .
Disclosure: The authors have no conflicts of intrest and no relevant financial relation with any organisation.

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