Remyelination: insights from mouse models and transcriptomic studies
ECTRIMS Online Library. Castelo-Branco G. 09/13/19; 279579; 324
Goncalo Castelo-Branco
Goncalo Castelo-Branco
Contributions
Abstract

Abstract: 324

Type: Educational Session

Abstract Category: Educational Session 26: Which remyelination strategies are most prom

G. Castelo-Branco

Karolinska Institutet, Stockholm, Sweden

Oligodendrocytes are glial cells that mediate myelination of neurons, a process that allows efficient electrical impulse transmission in the central nervous system (CNS). An autoimmune response against myelin triggers demyelination in multiple sclerosis (MS). Oligodendrocyte precursor cells (OPCs) are thought to initially differentiate and promote remyelination in MS, but this process eventually fails in progressive MS. Several mouse models of remyelination, such as lysolecithin, cuprizone, and experimental autoimmune encephalomyelitis (EAE), have been used in recent years to uncover biological mechanisms underlying remyelination. In this presentation, I will focus on insights already provided by transcriptomic studies in these models, at the population and single-cell level, and on their potential for the identification of novel targets at the molecular and cellular level to induce remyelination.
Disclosure: Swedish Research Council, European Union, Cancerfonden, Swedish Brain Foundation, Stockholm City Council, Ming Wai Lau Centre for Reparative Medicine, Karolinska Institutet and F. Hoffman - La Roche.

Abstract: 324

Type: Educational Session

Abstract Category: Educational Session 26: Which remyelination strategies are most prom

G. Castelo-Branco

Karolinska Institutet, Stockholm, Sweden

Oligodendrocytes are glial cells that mediate myelination of neurons, a process that allows efficient electrical impulse transmission in the central nervous system (CNS). An autoimmune response against myelin triggers demyelination in multiple sclerosis (MS). Oligodendrocyte precursor cells (OPCs) are thought to initially differentiate and promote remyelination in MS, but this process eventually fails in progressive MS. Several mouse models of remyelination, such as lysolecithin, cuprizone, and experimental autoimmune encephalomyelitis (EAE), have been used in recent years to uncover biological mechanisms underlying remyelination. In this presentation, I will focus on insights already provided by transcriptomic studies in these models, at the population and single-cell level, and on their potential for the identification of novel targets at the molecular and cellular level to induce remyelination.
Disclosure: Swedish Research Council, European Union, Cancerfonden, Swedish Brain Foundation, Stockholm City Council, Ming Wai Lau Centre for Reparative Medicine, Karolinska Institutet and F. Hoffman - La Roche.

By clicking “Accept Terms & all Cookies” or by continuing to browse, you agree to the storing of third-party cookies on your device to enhance your user experience and agree to the user terms and conditions of this learning management system (LMS).

Cookie Settings
Accept Terms & all Cookies